Illustration for Juricic's et al. (2022) study on the memory effect of anti-ageing drug rapamycin, published as the cover of Nature Aging in September 2022.
The research shows that a brief exposure to rapamycin in early adulthood has the same geroprotective effects as lifelong treatment in fruit flies and mice. This long-lasting geroprotection from rapamycin is achieved by a persistent increase in intestinal autophagy. The cover depicts a memory card game, highlighting the ‘memory effects’ of rapamycin on flies, mice, the gut and the autophagy machinery.
